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Scientist I, Immunology - job post

IAVI
4 reviews
Delhi
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Job type

  • Full-time

Location

Delhi

Full job description

Position Description

Job Title: Scientist I, Immunology
Location: Antibody Translational Research Program (ATRP), Faridabad, India
Reports to: Country Director, India

Position Summary:

IAVI is seeking a motivated and experienced Scientist to lead and ensure scientifically robust execution of R&D projects in alignment with the scientific mandate of the ATRP and IAVI. The Scientist works on priority disease areas such as HIV-1, SARS-CoV-2 amongst others. The Scientist plans and leads the expansion of research in areas of B-cell immunology, preclinical and clinical assay development, and uses standard platforms for antibody discovery and repertoire analysis such as single B cell sorting and 10x genomics sequencing.

Key Responsibilities:

  • Leads ATRP’s research projects’ implementation through development of scientific strategy, execution of experimental plans, data evaluation and interpretation, and results presentation.
  • Ensures overall scientific excellence and quality of data outputs of the projects by troubleshooting of assays/protocols, optimization of standard operating procedures and processes as well as reviewing scientific data to meet global standards in coordination with ATRP leadership.
  • Leads development, optimization, qualification, and validation of assays.
  • Executes on multi-color flow cytometry and FACS with advanced proficiency.
  • Mentors and trains junior research associates.
  • Contributes to transfer of technical methodologies/assay to cross-functional internal or external groups as required.
  • Contributes to the development of new research proposals in alignment with ATRP’s scientific mandate, and execution of the projects with internal / external teams or collaborators.
  • Works in close partnership and coordination with translational research and product development teams at IAVI.

Education and Work Experience:

  • PhD in Immunology or a related discipline is required.
  • Minimum 3 years of work experience post PhD with focus on immunology, vaccine research for infectious diseases with high quality publications, is required.
  • Experience in vaccine or, clinical research, or product development is highly desirable.

Qualifications and Skills:

  • Proficiency in B-cell biology, including assay development and qualification is required.
  • Experience with multi-color flow cytometry, encompassing panel design, cell sorting, and data analysis using software such as DIVA, FlowJo, and GraphPad.
  • Experience critically assessing data and methods and lead troubleshooting investigations is required.
  • Experience in independently handling funded grants/projects is required.
  • A good-track of peer-reviewed, high-impact publications in the desired area is required.
  • Ability to project manage effectively including maintenance of laboratory notebooks, computer file organization, data management is required.
  • Self-driven, highly motivated and result oriented strategic thinker, with ability to meet deadlines in a fast-paced quickly changing environment is required.
  • Interpersonal skills with proven ability to develop relationships and work collaboratively in teams with others from a range of disciplines and cultures is required.
  • Excellent written and oral communication is required.
  • Desirable skills include single- cell RNA sequencing (ideally 10x Genomics), immunological assays, BSL-3 pathogen experience, cell culture expertise, and familiarity with bioinformatic platforms (R software, SPSS).

Organizational Overview:

IAVI is a nonprofit scientific research organization dedicated to addressing urgent, unmet global health challenges including HIV and tuberculosis. Our mission is to translate scientific discoveries into affordable, globally accessible public health solutions. Through scientific and clinical research in Africa, India, Europe, and the U.S., IAVI is pioneering the development of biomedical innovations designed for broad global access. We develop vaccines and antibodies in and for the developing world and seek to accelerate their introduction in low-income countries. IAVI programs and partnerships are grounded in the regions of the world where the disease burden is the greatest, and our approach emphasizes sustainability. Our network of clinical research center partners in Africa and India helps strengthen in-country research capacity and supports the training and education of the next generation of scientists. The global impact of our science includes fundamental contributions to understanding the biology of HIV infection, which IAVI and others are applying toward advancing vaccine science and immunology. IAVI accelerates scientific discovery and development by fostering unique collaborations among academia, industry, local communities, governments, and funders to explore new and better ways to address public health threats that disproportionately affect people living in poverty. Our global reach, including a clinical research network in five countries in sub-Saharan Africa and in India, has allowed us to make fundamental contributions to understanding the epidemiology, transmission, virology, and immunology of HIV. This work played a key role in facilitating the design of promising HIV vaccine candidates, as well as the discovery of broadly neutralizing antibodies that are now being advanced as promising approaches for HIV prevention. Our integrated capabilities in vaccine and antibody discovery, development, and clinical research take advantage of bio-pharmaceutical industry expertise to accelerate the development and testing of prevention methods for HIV and other diseases. Through the Product Development Center, we support external researchers with technical and scientific expertise to accelerate the development of their own products.

About ATRP:

The Antibody Translational Research Program (ATRP) is a joint collaborative program between IAVI and Translational Health Science and Technology Institute (THSTI), for developing antibodies and vaccines against HIV/AIDS, TB, emerging infectious diseases like COVID-19 and RSV, and other regional and global health threats. It is located at the NCR Biotech Science Cluster in Faridabad, India and closely linked with IAVI’s Neutralizing Antibody Center (NAC), USA and its global network of laboratories, including those in Africa. ATRP has also established partnerships with leading academic labs in India & globally, for conducting research & building capacities for facilitating indigenous scientific innovation in and between LMICs.

The program comprises of an interdisciplinary group of scientists from both IAVI and THSTI with unique capabilities and multifaceted experience, which enable it to drive the mandate of vaccine and antibody research. The science at ATRP is driven on understanding the HIV-1 virus through genetic and functional characterization to inform development of region-specific HIV prevention products; discovery and development of novel mAbs; evaluate of host-immune responses induced by natural infection and post vaccination; and characterization of B-cell repertoire using next-generation technologies to inform further development of novel vaccines and antibodies.

IAVI CORE VALUES:

  • Dedication to the Mission: We are committed to the translation of scientific discoveries into affordable, globally accessible public health solutions.
  • Innovative Evolution: We are committed to solving complex problems in creative and innovative ways, learning from our mistakes and successes and never giving up
  • Integrity: We are committed to meeting the highest ethical and professional standards in everything we do and to taking responsibility for our actions to earn respect
  • Collaboration: We are committed to embracing diversity, the power of global teamwork and the belief that by working as one we can make a difference

Disclaimer: Nothing in this job description restricts management's right to assign or reassign duties and responsibilities to this job at any time. The above statements are intended to describe the general nature and level of work being performed by individuals assigned to this position. They are not intended to be an exhaustive list of all duties, responsibilities and skills required of personnel so classified. This document does not create an employment contract, implied or otherwise, other than an “at-will” relationship. IAVI is an equal opportunity employer and applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

IAVI IS AN EQUAL OPPORTUNITY EMPLOYER actively committed to fostering a diverse and inclusive global organization. IAVI believes that diversity and inclusion among our teammates is critical, and we seek to recruit, develop and retain the most talented people from a representative candidate pool. At IAVI, we celebrate the spectrum of colleagues’ experiences and believe that dedication to our mission above all is essential to our success as a scientific global non-profit. IAVI upholds these principles through IAVI’s Global Diversity and Inclusion Committee.

IAVI has zero tolerance for discrimination or harassment on the basis of race, color, ethnicity, caste, national origin, home language, ancestry, religion, marital or civil partnership status, age, physical or mental disability, HIV status and any other medical condition, genetic information, pregnancy, sexual orientation, gender identity or expression, and veteran status, in addition to any other status protected under the law in any of our locations worldwide.

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